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By Frances M. Ashcroft

Ion channels are membrane proteins that act as gated pathways for the flow of ions throughout mobile membranes. They play crucial roles within the body structure of all cells. in recent times, an ever-increasing variety of human and animal illnesses were chanced on to end result from defects in ion channel functionality. almost all these ailments come up from mutations within the genes encoding ion channel proteins, and they're now often called the channelopathies.

Ion Channels and Disease offers an informative and up to date account of our current realizing of ion channels and the molecular foundation of ion channel ailments. It incorporates a uncomplicated advent to the correct elements of molecular biology and biophysics and a quick description of the imperative equipment used to review channelopathies. for every channel, the connection among its molecular constitution and its practical homes is mentioned and ways that genetic mutations produce the illness phenotype are considered.

This ebook is meant for learn employees and clinicians, in addition to graduates and complex undergraduates. The textual content is apparent and full of life and assumes little wisdom, but it takes the reader to frontiers of what's at the moment identified approximately this most enjoyable and medically very important sector of physiology.

  • Introduces the correct points of molecular biology and biophysics
  • Describes the valuable tools used to review channelopathies
  • Considers unmarried periods of ion channels with summaries of the physiological position, subunit composition, molecular constitution and chromosomal position, plus the connection among channel constitution and function
  • Looks at these ailments linked to faulty channel buildings and legislation, together with mutations affecting channel functionality and to what quantity this alteration in channel functionality can account for the medical phenotype

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Ion Channels and Disease: Channelopathies (Quantitative Finance) by Frances M. Ashcroft


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